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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

Warhammer Age of Sigmar Warriors of Chaos Blood Warriors 32125mm napoleonic french - revolutionary line 19 figures - inf (31268)LOTR Giant Eagle (Direct Only) Metal Boxed Set  Continue reading “Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study”

WAKE-UP Time for Thrombolysis in Acute Stroke?

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By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”


By Olivier Lucar
October 16, 2018

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By Connor Emdin
September 26, 2018

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Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.Citadel metal c23 giant ogre, Chaos Ogre, good condition, no base nub, warhammer Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?


By Martina McGrath, MD
July 18, 2018

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TRI-ANG Dust Cart Refuse Lorry Tinplate-32M MINIC nyrupp1374-Clockwork/Wind-Up

Item specifics

Used: An item that has been previously used. See the seller’s listing for full details and description of ... Read moreabout the condition
Specific Character: Delivery open back lorry
Age Level: Collector's toy Subtype: Clockwork/ Wind-Up
Country/Region of Manufacture: United Kingdom Modified Item: No
TV/ Film Character: No Character Type: Tri-ang Minic Vintage/ Classic Toys

Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

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By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

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By Martina McGrath, MD
June 5, 2018

Flames of War US M3 LEE TANK PLATOON 15mm UBX50Games Workshop Citadel Realms of Chaos Thugs CH6 Link Cutter 1987 Blister New GW Kanday Kingdom Module 1986 Columbia Games (Harn Fantasy System)

25mm medieval saracen - light 10 figures - cav (29601)

10mm roman era late roman - legionaries 42 figures - inf (27689)

By Lea Borgi, MD
May 16, 2018

15mm ACW confederate - regiment 24 figures - inf (24034)LOTHERN SEAGUARD - WARHAMMER FANTASY AGE OF SIGMAR - GAMES WORKSHOP15mm ACW confederate - mounted & dismounted 22 figures - cav (27442) Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”