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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?


By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

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By Olivier Lucar
October 16, 2018

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By Connor Emdin
September 26, 2018

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Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.LEGO Legoland 6685 Fire Copter Helicopter 100% CORRECT with instructions Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

LEGO NINJAGO (Ninja Nightcrawler 2018)

By Martina McGrath, MD
July 18, 2018

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Duplo Lego Mixed Large 250 plus peices - Assortment nyrfav1774-LEGO Bricks & Building Pieces

Item specifics

Used: An item that has been previously used. See the seller’s listing for full details and description of ... Read moreabout the condition
Brand: Lego
Product Line (LEGO Theme): Duplo LEGO Character: Assorted

Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

LEGO Super Heroes BatmanTM Gotham City Cycle Chase 76053 RETIRED, BRAND NEW

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

LEGO City Heavy-duty Rescue Helicopter 2017 (60166) - NEW BOXED SEALED

By Martina McGrath, MD
June 5, 2018

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New Lego DC 76053 Gotham City Cycle Chase. Batman, Harley Quinn, Deadshot.

Lego Star Wars Bobba Fett's Slave Ship Manual Box But No Figures 7153

By Lea Borgi, MD
May 16, 2018

Lego Aqua Raiders 7774 Crab Crusher BNIBLego 75929 Jurassic World Carnotaurus Gyrosphere Escape Building SetLEGO Scout Trooper and Speeder Bike Construction Toy Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”